A single weak vent is exactly the pattern duct leakage tends to produce when it is localized: a torn or poorly sealed joint on one branch bleeds air out before it reaches that room's register, while every other branch delivers normally because it is unaffected.
This is different from whole-house weak airflow, which usually points to a shared restriction like a filter or blower. A duct leakage test, combined with a physical inspection of the branch, distinguishes a leak from a crushed duct, a closed damper, or a disconnection — each of which needs a different fix.